A synthetic octapeptide that works directly on the gut's tight junctions to reduce intestinal permeability. The most clinically studied compound for leaky gut — with multiple Phase 2 and Phase 3 trials in celiac disease patients.
What is this used for?
How do you take it?
These are typical doses from research and real prescriptions — not a recommendation for you specifically. Your provider will adjust based on your body, your goals, and your health history.
How well researched is this?
Strong Animal & Lab Research
Multiple Phase 2 and Phase 3 trials in celiac disease patients. Human clinical data confirms safety and improvements in tight junction integrity and GI symptoms.
Legal status
Currently restricted by the FDA and cannot be legally compounded. This status may change — we'll update this page when it does.
2026 reclassification status updates coming soon.
Purity
Purity measures how clean and accurate the compound is. Higher purity means fewer contaminants and more reliable dosing.
HPLC Purity Tested
Always require a Certificate of Analysis (CoA) from a US-based compounding pharmacy.
Common questions
Ready to start?
Consult with a licensed provider to determine the right protocol for your goals.